Citrullination Inactivates Nicotinamide-N-methyltransferase
Abstract
Nicotinamide-N-methyltransferase (NNMT) catalyzes the irreversible methylation of nicotinamide (NAM) to form N-methyl nicotinamide using S-adenosyl methionine as a methyl donor. NNMT is implicated in several chronic disease conditions, including cancers, kidney disease, cardiovascular disease, and Parkinson’s disease. Although phosphorylation of NNMT in gastric tumors is reported, the functional effects of this post-translational modification...
Paper Details
Title
Citrullination Inactivates Nicotinamide-N-methyltransferase
Published Date
Jul 25, 2018
Journal
Volume
13
Issue
9
Pages
2663 - 2672
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