Original paper
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
Abstract
Metformin, the universal first-line treatment for type 2 diabetes, exerts its therapeutic glucose-lowering effects by inhibiting hepatic gluconeogenesis. However, the primary molecular mechanism of this biguanide remains unclear, though it has been suggested to act, at least partially, by mitochondrial complex I inhibition. Here we show that clinically relevant concentrations of plasma metformin achieved by acute intravenous, acute intraportal...
Paper Details
Title
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
Published Date
Jul 23, 2018
Journal
Volume
24
Issue
9
Pages
1384 - 1394
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Notes
History