The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities

Volume: 43, Issue: 9, Pages: 726 - 739
Published: Sep 1, 2018
Abstract
The rhomboid superfamily of transmembrane (TM) proteins includes intramembrane serine proteases and several classes of pseudoprotease. Rhomboid-like proteins occur widely across evolution and comprise biologically important regulators of fate of membrane proteins, influencing their proteolysis, trafficking, or degradation. In this review, we discuss how structural and mechanistic insights into the action of rhomboid proteases can inform on the...
Paper Details
Title
The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities
Published Date
Sep 1, 2018
Volume
43
Issue
9
Pages
726 - 739
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