Review paper
The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy
Abstract
The DNA repair protein, O 6 -methylguanine DNA methyltransferase (MGMT), can confer resistance to guanine O 6 -alkylating agents. Therefore, inhibition of resistant MGMT protein is a practical approach to increase the anticancer effects of such alkylating agents. Numerous small molecule inhibitors were synthesized and exhibited potential MGMT inhibitory activities. Although they were nontoxic alone, they also inhibited MGMT in normal tissues,...
Paper Details
Title
The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy
Published Date
Aug 1, 2018
Journal
Volume
10
Issue
16
Pages
1971 - 1996
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History