Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
Abstract
In patients with Charcot–Marie–Tooth disease 1A (CMT1A), peripheral nerves display aberrant myelination during postnatal development, followed by slowly progressive demyelination and axonal loss during adult life. Here, we show that myelinating Schwann cells in a rat model of CMT1A exhibit a developmental defect that includes reduced transcription of genes required for myelin lipid biosynthesis. Consequently, lipid incorporation into myelin is...
Paper Details
Title
Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
Published Date
Aug 2, 2018
Journal
Volume
9
Issue
1
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