Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson’s Disease Patients
Abstract
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. While most PD cases are idiopathic, the known genetic causes of PD are useful to understand common disease mechanisms. Recent data suggests that autophagy is regulated by protein acetylation mediated by histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities. The changes in histone acetylation reported to be involved in PD pathogenesis have...
Paper Details
Title
Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson’s Disease Patients
Published Date
Jul 21, 2018
Journal
Volume
56
Issue
4
Pages
2466 - 2481
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