Systematic Study of Nucleosome-Displacing Factors in Budding Yeast
Abstract
Nucleosomes present a barrier for the binding of most transcription factors (TFs). However, special TFs known as nucleosome-displacing factors (NDFs) can access embedded sites and cause the depletion of the local nucleosomes as well as repositioning of the neighboring nucleosomes. Here, we developed a novel high-throughput method in yeast to identify NDFs among 104 TFs and systematically characterized the impact of orientation, affinity,...
Paper Details
Title
Systematic Study of Nucleosome-Displacing Factors in Budding Yeast
Published Date
Jul 1, 2018
Journal
Volume
71
Issue
2
Pages
294 - 305.e4
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