N6-Methyladenosine–binding proteins suppress HIV-1 infectivity and viral production

Volume: 293, Issue: 34, Pages: 12992 - 13005
Published: Aug 24, 2018
Abstract
The internal N6-methyladenosine (m6A) modification of cellular mRNA regulates post-transcriptional gene expression. The YTH domain family proteins (YTHDF1–3 or Y1–3) bind to m6A-modified cellular mRNAs and modulate their metabolism and processing, thereby affecting cellular protein translation. We previously reported that HIV-1 RNA contains the m6A modification and that Y1–3 proteins inhibit HIV-1 infection by decreasing HIV-1 reverse...
Paper Details
Title
N6-Methyladenosine–binding proteins suppress HIV-1 infectivity and viral production
Published Date
Aug 24, 2018
Volume
293
Issue
34
Pages
12992 - 13005
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