Host-Intrinsic Interferon Status in Infection and Immunity
Abstract
Low activation levels of cGAS/STING during DNA damage increase baseline IFN signaling and enhance cellular response to viral and bacterial infection, indicating a protective role for constitutive IFN. Mitochondrial damage releases DNA into the cytosol, and the ensuing activation of cGAS/STING has been shown to induce an IFN response that results in pathology or lethality, thus implicating elevated host-intrinsic IFN status with cell death and...
Paper Details
Title
Host-Intrinsic Interferon Status in Infection and Immunity
Published Date
Aug 1, 2018
Journal
Volume
24
Issue
8
Pages
658 - 668
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