Neisseria meningitidis serogroup B lipopolysaccharides induce a lower pro-inflammatory effect within the proteoliposome used in Cuban anti-meningococcal vaccines

Neisseria meningitidis outer membrane vesicles or proteoliposomes (PLs) have been used as vaccines and adjuvants. Despite the presence of potentially toxic amounts of lipopolysaccharide (LPS), they have been shown to be safe, well tolerated, and immunogenic. This suggests that LPS-PL may have reduced LPS toxicity. In this study, it is shown that the ability of PL to induce pro-inflammatory cytokine production in human U937 histiocytic cell line...