USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination

Volume: 14, Issue: 11, Pages: 1976 - 1990
Published: Aug 10, 2018
Abstract
Recent reports have made important revelations, uncovering direct regulation of DNA damage response (DDR)-associated proteins and chromatin ubiquitination (Ubn) by macroautophagy/autophagy. Here, we report a previously unexplored connection between autophagy and DDR, via a deubiquitnase (DUB), USP14. Loss of autophagy in prostate cancer cells led to unrepaired DNA double-strand breaks (DSBs) as indicated by persistent ionizing radiation...
Paper Details
Title
USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination
Published Date
Aug 10, 2018
Journal
Volume
14
Issue
11
Pages
1976 - 1990
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