Phenotype molding of stromal cells in the lung tumor microenvironment
Abstract
Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human lung tumors at single-cell resolution, validated in independent samples where 40,250 additional cells were sequenced. By comparing with matching non-malignant lung samples, we reveal a highly complex TME that profoundly molds stromal cells. We identify 52 stromal cell...
Paper Details
Title
Phenotype molding of stromal cells in the lung tumor microenvironment
Published Date
Jul 9, 2018
Journal
Volume
24
Issue
8
Pages
1277 - 1289
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