Trinucleotide repeat instability during double-strand break repair: from mechanisms to gene therapy
Abstract
Trinucleotide repeats are a particular class of microsatellites whose large expansions are responsible for at least two dozen human neurological and developmental disorders. Slippage of the two complementary DNA strands during replication, homologous recombination or DNA repair is generally accepted as a mechanism leading to repeat length changes, creating expansions and contractions of the repeat tract. The present review focuses on recent...
Paper Details
Title
Trinucleotide repeat instability during double-strand break repair: from mechanisms to gene therapy
Published Date
Jul 5, 2018
Journal
Volume
65
Issue
1
Pages
17 - 28
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