Cover Feature: A DNA‐Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition (ChemMedChem 13/2018)

The Cover Feature shows the affinity capture of small organic compounds encoded by a DNA fragment, serving as amplifiable identification barcode. The technology enabled the discovery of a nanomolar ligand for human tankyrase-1 (TNKS1), starting from an encoded combinatorial library which featured seven different central scaffolds, functionalized with two sets of chemical building blocks. More information can be found in the Communication by...