Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification
Abstract
Use of the diabetes type II drug Metformin is associated with a moderately lowered risk of cancer incidence in numerous tumor entities. Studying the molecular changes associated with the tumor-suppressive action of Metformin we found that the oncogene SOX4 , which is upregulated in solid tumors and associated with poor prognosis, was induced by Wnt/β-catenin signaling and blocked by Metformin. Wnt signaling inhibition by Metformin was...
Paper Details
Title
Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification
Published Date
Jul 3, 2018
Journal
Volume
4
Issue
1
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