Aberrant activation of the type I interferon system may contribute to the pathogenesis of anti‐melanoma differentiation‐associated gene 5 dermatomyositis

Anti‐melanoma differentiation‐associated gene 5 (MDA5) dermatomyositis (DM) is a distinctive subtype of DM that carries a significant risk of interstitial lung disease (ILD). The mechanisms remain elusive. To explore the role of the type I interferon (IFN) system in the pathogenesis of anti‐MDA5 DM. Twenty patients with anti‐MDA5 DM were studied and compared with patients with anti‐aminoacyl‐tRNA synthetase (ARS) DM (n = 10) and...