A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice
Abstract
The FGF/ERK signaling pathway is highly conserved throughout evolution and plays fundamental roles during embryonic development and in adult organisms. While a plethora of expression data exists for ligands, receptors and pathway regulators, we know little about the spatial organization or dynamics of signaling in individual cells within populations. To this end we developed a transcriptional readout of FGF/ERK activity by targeting a histone...
Paper Details
Title
A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice
Published Date
Sep 1, 2018
Journal
Volume
441
Issue
1
Pages
104 - 126
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Notes
History