Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism

Local myonecrosis is the main event resulting from snakebite envenomation by the Bothrops genus and, frequently, it is not efficiently neutralized by antivenom administration. Proteases, phospholipases A 2 (PLA 2 ) and PLA 2 -like toxins are found in venom related to muscle damage. Functional sites responsible for PLA 2 -like toxins activity have been proposed recently; they consist of a membrane docking-site and a membrane rupture-site. Herein,...