Substrate relay in an Hsp70‐cochaperone cascade safeguards tail‐anchored membrane protein targeting
Abstract
Membrane proteins are aggregation-prone in aqueous environments, and their biogenesis poses acute challenges to cellular protein homeostasis. How the chaperone network effectively protects integral membrane proteins during their post-translational targeting is not well understood. Here, biochemical reconstitutions showed that the yeast cytosolic Hsp70 is responsible for capturing newly synthesized tail-anchored membrane proteins (TAs) in the...
Paper Details
Title
Substrate relay in an Hsp70‐cochaperone cascade safeguards tail‐anchored membrane protein targeting
Published Date
Jul 4, 2018
Journal
Volume
37
Issue
16
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Notes
History