Phenotypic characterization of murine models of cerebral cavernous malformations
Abstract
Cerebral cavernous malformations (CCMs) are clusters of dilated capillaries that affect around 0.5% of the population. CCMs exist in two forms, sporadic and familial. Mutations in three documented genes, KRIT1(CCM1), CCM2, and PDCD10(CCM3), cause the autosomal dominant form of the disease, and somatic mutations in these same genes underlie lesion development in the brain. Murine models with constitutive or induced loss of respective genes have...
Paper Details
Title
Phenotypic characterization of murine models of cerebral cavernous malformations
Published Date
Mar 1, 2019
Journal
Volume
99
Issue
3
Pages
319 - 330
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