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Melanin-Concentrating Hormone-Dependent Control of Feeding: When Volume Matters.

Published on Jul 3, 2018in Cell Metabolism22.415
· DOI :10.1016/J.CMET.2018.06.018
Hong Jiang2
Estimated H-index: 2
(MPG: Max Planck Society),
Jens C. Brüning72
Estimated H-index: 72
(MPG: Max Planck Society)
Sources
Abstract
In contrast to synaptic transmission, the mechanism of volume transmission—in which neurotransmitters or neuropeptides diffuse to many effector cells—is not extensively investigated, although it represents an important mode of neuronal communication. In this issue of Cell Metabolism, Noble et al. (2018) demonstrate how the orexigenic melanin-concentrating hormone (MCH) controls feeding behavior through cerebrospinal fluid (CSF) volume transmission.
  • References (12)
  • Citations (3)
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References12
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#1Emily E. Noble (SC: University of Southern California)H-Index: 17
#2Joel D. Hahn (SC: University of Southern California)H-Index: 18
Last. Scott E. Kanoski (SC: University of Southern California)H-Index: 32
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Summary Classical mechanisms through which brain-derived molecules influence behavior include neuronal synaptic communication and neuroendocrine signaling. Here we provide evidence for an alternative neural communication mechanism that is relevant for food intake control involving cerebroventricular volume transmission of the neuropeptide melanin-concentrating hormone (MCH). Results reveal that the cerebral ventricles receive input from approximately one-third of MCH-producing neurons. Moreover,...
26 CitationsSource
#1Laura E. Mickelsen (UConn: University of Connecticut)H-Index: 4
#2Fredrick W. Kolling (UConn: University of Connecticut)H-Index: 1
Last. Alexander C. Jackson (UConn: University of Connecticut)H-Index: 17
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Abstract The lateral hypothalamic area (LHA) lies at the intersection of multiple neural and humoral systems and orchestrates fundamental aspects of behavior. Two neuronal cell types found in the LHA are defined by their expression of hypocretin/orexin (Hcrt/Ox) and melanin-concentrating hormone (MCH) and are both important regulators of arousal, feeding, and metabolism. Conflicting evidence suggests that these cell populations have a more complex signaling repertoire than previously appreciated...
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#1A. Christine Hausen (MPG: Max Planck Society)H-Index: 4
#2Johan Ruud (MPG: Max Planck Society)H-Index: 4
Last. Jens C. BrüningH-Index: 72
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Summary Melanin-concentrating-hormone (MCH)-expressing neurons (MCH neurons) in the lateral hypothalamus (LH) are critical regulators of energy and glucose homeostasis. Here, we demonstrate that insulin increases the excitability of these neurons in control mice. In vivo, insulin promotes phosphatidylinositol 3-kinase (PI3K) signaling in MCH neurons, and cell-type-specific deletion of the insulin receptor (IR) abrogates this response. While lean mice lacking the IR in MCH neurons (IR ΔMCH ) exhi...
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#2Zhen Fang Huang Cao (Janelia Farm Research Campus)H-Index: 9
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Neural circuits for essential natural behaviors are shaped by selective pressure to coordinate reliable execution of flexible goal-directed actions. However, the structural and functional organization of survival-oriented circuits is poorly understood due to exceptionally complex neuroanatomy. This is exemplified by AGRP neurons, which are a molecularly defined population that is sufficient to rapidly coordinate voracious food seeking and consumption behaviors. Here, we use cell-type-specific te...
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The growing prevalence of overeating disorders is a key contributor to the worldwide obesity epidemic. Dysfunction of particular neural circuits may trigger deviations from adaptive feeding behaviors. The lateral hypothalamus (LH) is a crucial neural substrate for motivated behavior, including feeding, but the precise functional neurocircuitry that controls LH neuronal activity to engage feeding has not been defined. We observed that inhibitory synaptic inputs from the extended amygdala preferen...
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Neurons within the central nervous system receive humoral and central (neurotransmitter or neuropeptide) signals that ultimately regulate ingestive behavior and metabolism. Recent advances in mouse genetics combined with neuroanatomical and electrophysiological techniques have contributed to a better understanding of these central mechanisms. This review integrates recently defined cellular mechanisms and neural circuits relevant to the regulation of feeding behavior, energy expenditure, and glu...
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#1Benjamin B. Whiddon (UW: University of Washington)H-Index: 3
#2Richard D. Palmiter (UW: University of Washington)H-Index: 130
Melanin-concentrating hormone (MCH)-expressing neurons have been ascribed many roles based on studies of MCH-deficient mice. However, MCH neurons express other neurotransmitters, including GABA, nesfatin, and cocaine–amphetamine-regulated transcript. The importance of these other signaling molecules made by MCH neurons remains incompletely characterized. To determine the roles of MCH neurons in vivo , we targeted expression of the human diphtheria toxin receptor (DTR) to the gene for MCH ( Pmch ...
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#1Deniz Atasoy (HHMI: Howard Hughes Medical Institute)H-Index: 21
#2J. Nicholas Betley (HHMI: Howard Hughes Medical Institute)H-Index: 15
Last. Scott M. Sternson (HHMI: Howard Hughes Medical Institute)H-Index: 30
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Using optogenetic and pharmacogenetic techniques, the authors find that AGRP neurons suppress oxytocin-releasing neurons, which is a critical interaction for evoked feeding; thus they identify a circuit potentially involved in regulating hunger state.
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Abstract The dawn of chemical neuroanatomy in the CNS came with the discovery and mapping of the central dopamine, noradrenaline and 5-hydroxytryptamine neurons by means of transmitter histochemistry using the Falck–Hillarp formaldehyde fluorescence technique in the early 1960s. Our mapping of the central monoamine neurons was continued and further established with tyrosine hydroxylase, dopa decarboxylase and dopamine-beta-hydroxylase immunohistochemistry in collaboration with Menek Goldstein an...
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#1David S. Ludwig (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 67
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Several lines of investigation suggest that the hypothalamic neuropeptide melanin-concentrating hormone (MCH) regulates body weight in mammals. Obese mice lacking functional leptin overexpress the MCH message in the fed or fasted state. Acute intracerebroventricular injection of MCH increases energy intake in rats. Mice lacking the MCH gene are lean. To test the hypothesis that chronic overexpression of MCH in mice causes obesity, we produced transgenic mice that overexpress MCH (MCH-OE) in the ...
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Cited By3
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#1Giovanne B. Diniz (USP: University of São Paulo)H-Index: 1
#2Daniella S. Battagello (USP: University of São Paulo)H-Index: 4
Last. Antoine Roger Adamantidis (University of Bern)H-Index: 32
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Melanin-concentrating hormone (MCH) is a ubiquitous vertebrate neuropeptide predominantly synthesized by neurons of the diencephalon that can act through two G protein-coupled receptors, called MCHR1 and MCHR2. The expression of Mchr1 has been investigated in both rats and mice, but its synthesis remains poorly described. After identifying an antibody that detects MCHR1 with high specificity, we employed immunohistochemistry to map the distribution of MCHR1 in the CNS of rats and mice. Multiple ...
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#1Giovanne B. Diniz (USP: University of São Paulo)H-Index: 7
#2Daniella S. Battagello (UNAM: National Autonomous University of Mexico)H-Index: 4
Last. Jackson C. Bittencourt (USP: University of São Paulo)H-Index: 30
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: Melanin-concentrating hormone (MCH) is a conserved neuropeptide, predominantly located in the diencephalon of vertebrates, and associated with a wide range of functions. While functional studies have focused on the use of the traditional mouse laboratory model, critical gaps exist in our understanding of the morphology of the MCH system in this species. Even less is known about the nontraditional animal model Neotomodon alstoni (Mexican volcano mouse). A comparative morphological study among t...
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#1Giovanne B. Diniz (USP: University of São Paulo)H-Index: 7
#2Daniella S. Battagello (USP: University of São Paulo)H-Index: 4
Last. Jackson C. Bittencourt (USP: University of São Paulo)H-Index: 30
view all 13 authors...
Melanin-concentrating hormone (MCH) is a ubiquitous vertebrate neuropeptide predominantly synthesized by neurons of the diencephalon that can act through two G protein-coupled receptors, called MCHR1 and MCHR2. The expression of Mchr1 has been investigated in both rats and mice, but its synthesis remains poorly described. After identifying an antibody that detects MCHR1 with high specificity, we employed immunohistochemistry to map the distribution of MCHR1 in the CNS of rats and mice. Multiple ...
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