CpG island composition differences are a source of gene expression noise indicative of promoter responsiveness

Population phenotypic variation can arise from genetic differences between individuals, or from cellular heterogeneity in an isogenic group of cells or organisms. The emergence of gene expression differences between genetically identical cells is referred to as gene expression noise, the sources of which are not well understood. In this work, by studying gene expression noise between multiple cell lineages and mammalian species, we find...