Match!

Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis : A systematic review of randomised controlled trials

Published on Jun 22, 2018in British Journal of Sports Medicine11.64
· DOI :10.1136/bjsports-2017-098661
Alessio Bricca2
Estimated H-index: 2
,
Carsten Bogh Juhl15
Estimated H-index: 15
(UCPH: University of Copenhagen)
+ 2 AuthorsEwa M. Roos63
Estimated H-index: 63
Abstract
Objective To investigate the impact of knee joint loading exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis (OA) by conducting a systematic review of randomised controlled trials (RCTs). Design We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Data sources We performed a literature search with no restriction on publication year or language in MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Controlled Trials and Web of Science up to September 2017. Eligibility criteria RCTs investigating the impact of exercise on MRI-assessed articular cartilage in people over 18 years of age. Results We included nine trials, including a total of 14 comparisons of cartilage morphometry, morphology and composition outcomes, of which two included participants at increased risk of knee OA and 12 included participants with knee OA. In participants at increased risk, one study comparison reported no effect on cartilage defects and one had positive effects on glycosaminoglycans (GAG). In participants with OA, six study comparisons reported no effect on cartilage thickness, volume or defects; one reported a negative effect and one no effect on GAG; two reported a positive effect and two no effect on collagen. Conclusions Knee joint loading exercise seems to not be harmful for articular cartilage in people at increased risk of, or with, knee OA. However, the quality of evidence was low, including some interventions studying activities considered outside the therapeutic loading spectrum to promote cartilage health.
  • References (48)
  • Citations (9)
References48
Newest
#1Jean-Hugues Salmon (URCA: University of Reims Champagne-Ardenne)H-Index: 3
#2Anne-Christine Rat (Paris V: Paris Descartes University)H-Index: 17
Last.B. Fautrel (UPMC: Pierre-and-Marie-Curie University)H-Index: 25
view all 8 authors...
#1M.L. Landsmeer (EUR: Erasmus University Rotterdam)H-Index: 2
#2J. Runhaar (EUR: Erasmus University Rotterdam)H-Index: 11
Last.Sita M. A. Bierma-Zeinstra (EUR: Erasmus University Rotterdam)H-Index: 68
view all 9 authors...
Cited By9
Newest
View next paper8 Impact of knee joint loading exercise on MRI-assessed articular cartilage, in knee osteoarthritis: a systematic review of randomised controlled trials