Original paper
Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity
Abstract
Fatty acid (FA)-stimulated insulin secretion (FASIS) is reviewed here in contrast to type 2 diabetes etiology, resulting from FA overload, oxidative stress, intermediate hyperinsulinemia, and inflammation, all converging into insulin resistance. Focusing on pancreatic islet β-cells, we compare the physiological FA roles with the pathological ones. Considering FAs not as mere amplifiers of glucose-stimulated insulin secretion (GSIS), but as...
Paper Details
Title
Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity
Published Date
Jun 19, 2018
Journal
Volume
23
Issue
6
Pages
1483 - 1483
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Notes
History