Estimating Left Ventricular Elastance from Aortic Flow Waveform, Ventricular Ejection Fraction, and Brachial Pressure: An In Silico Study

Although left ventricular end-systolic elastance (Ees) serves as a major index of cardiac contractility, a widely-accepted noninvasive estimation of Ees does not exist. To overcome this limitation, we developed a two-step inverse method that allows for its noninvasive estimation from measurements of aortic flow and brachial pressure using a previously validated one-dimensional model of the cardiovascular system. In a first step, aortic flow is...