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Physical performance measures in screening for reduced lean body mass in adult females with obesity

Published on Sep 1, 2018in Nutrition Metabolism and Cardiovascular Diseases3.34
· DOI :10.1016/j.numecd.2018.06.008
M. El Ghoch5
Estimated H-index: 5
,
A Rossi56
Estimated H-index: 56
(University of Verona)
+ 7 AuthorsR. Dalle Grave10
Estimated H-index: 10
Cite
Abstract
Abstract Background & aims Little is known about the reduction of lean body mass (LBM) in obesity, or how to identify it in standard clinical settings. We therefore aimed to assess the prevalence of low LBM in adult females with obesity, and to identify the reliability of simple tools for its screening in this population. Methods and Results Dual-energy X-ray absorptiometry (DXA) body composition assessment was used to categorise 147 female participants with obesity as with or without low LBM, according to the new definition that takes into account both appendicular lean mass (ALM) and body mass index (BMI)—ALM/BMI Of the sample of 147 participants, 93 (63.3%) met the criteria for reduced LBM. Stepwise multivariate logistic regression analysis showed that the six-minute walking test was the only independent test associated with low LBM (OR = 0.992, 95%CI 0.987–0.998). Receiver operating characteristic (ROC) curve analysis found that the discriminating cut-off points of the tests considered were 470 m, 3.30 s (gait speed = 1.2 m/sec) and 23.5 kg respectively; the 4-metre gait-speed test seems to provide the best balance of sensitivity and specificity, and the greatest discriminatory power at 90% sensitivity. Conclusions Treatment-seeking adult females with obesity display a great prevalence of reduced LBM. The six-minute walking test was the only independent test associated with low LBM, but the 4-metre gait-speed test seems to be the most accurate functional test for screening for this condition in that population.
  • References (24)
  • Citations (4)
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References24
Newest
Published on Nov 1, 2017in European Journal of Clinical Investigation2.78
Svein Ivar Bekkelund19
Estimated H-index: 19
(UNN: University Hospital of North Norway),
Rolf Jorde54
Estimated H-index: 54
(UNN: University Hospital of North Norway)
Objective Obesity is associated with inflammation, but the role of lean mass and creatine kinase (CK) on the inflammatory process is less known. We investigated the associations between lean mass, CK and fat mass upon inflammatory parameters in an overweight and obese adult population. Methods Body composition measured with dual-energy X-ray absorptiometry, high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), CK and supplementary clinical parameters were measured i...
Published on Jul 6, 2017in The New England Journal of Medicine70.67
Ashkan Afshin30
Estimated H-index: 30
(UW: University of Washington),
Mohammad H. Forouzanfar56
Estimated H-index: 56
(UW: University of Washington)
+ 150 AuthorsMohsen Naghavi81
Estimated H-index: 81
(UW: University of Washington)
BACKGROUND Although the rising pandemic of obesity has received major attention in many countries, the effects of this attention on trends and the disease burden of obesity remain uncertain. METHOD ...
Published on Jan 1, 2017in Journal of Nutrition and Metabolism
Carlene Johnson Stoklossa6
Estimated H-index: 6
,
Arya M. Sharma29
Estimated H-index: 29
+ 3 AuthorsCarla M. Prado29
Estimated H-index: 29
Background/Objective. Sarcopenic obesity (SO) is a hidden condition of reduced lean soft tissue (LST) in context of excess adiposity. SO is most commonly reported in older adults and both its risk and prevalence increase with age. A variety of body composition indices and cut points have been used to define this condition, leading to conflicting prevalence and risk prediction. Here, we investigate variability in the prevalence of SO in an adult sample of individuals with class II/III obesity (BM...
Published on Apr 14, 2016in PLOS ONE2.78
Marcello Maggio40
Estimated H-index: 40
(University of Parma),
Gian Paolo Ceda29
Estimated H-index: 29
(University of Parma)
+ 8 AuthorsMassimo Fabi2
Estimated H-index: 2
Background Manual measurement of 4-meter gait speed by a stopwatch is the gold standard test for functional assessment in older adults. However, the accuracy of this technique may be biased by several factors, including intra- and inter-operator variability. Instrumental techniques of measurement using accelerometers may have a higher accuracy. Studies addressing the concordance between these two techniques are missing. The aim of the present community-based observational study was to compare ma...
Published on Jan 1, 2016in Diabetes & Metabolism Journal
Yaeko Fukushima4
Estimated H-index: 4
(Kansai Medical University),
Satoshi Kurose5
Estimated H-index: 5
(Kansai Medical University)
+ 4 AuthorsYutaka Kimura12
Estimated H-index: 12
(Kansai Medical University)
It has recently been suggested that skeletal muscle has an important role in insulin resistance in obesity, in addition to exercise tolerance and the fat index. The aim of this study was to identify body composition factors that contribute to improvement of insulin resistance in female patients with obesity who reduce body weight.We studied 92 female obese patients (age 40.9±10.4 years, body mass index 33.2±4.6 kg/m²) who reduced body weight by ≥5% after an intervention program including diet, e...
Published on Jan 1, 2015in Journal of Clinical Medicine Research
Hidekatsu Yanai17
Estimated H-index: 17
Aging-related sarcopenia means that muscle mass, strength, and physical performance tend to decline with age, and malnutrition is associated with sarcopenia. Therefore, nutritional interventions may make an important contribution to prevent the development of sarcopenia. Here I reviewed published articles about the effects of nutritional factors on sarcopenia in elderly people. A growing body of evidence suggests that metabolic factors associated with obesity and diabetes induce the progression ...
Stephanie A. Studenski72
Estimated H-index: 72
(University of Pittsburgh),
Katherine W. Peters12
Estimated H-index: 12
(CPMC: California Pacific Medical Center)
+ 12 AuthorsAnne M. Kenny41
Estimated H-index: 41
(University of Connecticut Health Center)
Background. Low muscle mass and weakness are common and potentially disabling in older adults, but in order to become recognized as a clinical condition, criteria for diagnosis should be based on clinically relevant thresholds and independently validated. The Foundation for the National Institutes of Health Biomarkers Consortium Sarcopenia Project used an evidence-based approach to develop these criteria. Initial findings were presented at a conference in May 2012, which generated recommendation...
Published on Mar 1, 2014in Obesity3.97
Melpomeni Peppa25
Estimated H-index: 25
(Athens State University),
Chrysi Koliaki10
Estimated H-index: 10
(Athens State University)
+ 7 AuthorsGeorge Dimitriadis27
Estimated H-index: 27
(Athens State University)
Objective: Aim of this study was to investigate the association of total and regional lean body mass (LBM) with cardiometabolic risk factors in healthy obese and nonobese postmenopausal women. Methods: A total of 150 postmenopausal women (age 54 ± 7 years, BMI 29.6 ± 5.8 kg/m2) underwent a comprehensive assessment of cardiometabolic risk, including metabolic syndrome (MS). Body composition analysis was performed with Dual-energy X-ray Absorptiometry, and multiple height-adjusted indices of total...
Published on Oct 11, 2013in PLOS ONE2.78
Lorenzo M. Donini30
Estimated H-index: 30
(Sapienza University of Rome),
Eleonora Poggiogalle14
Estimated H-index: 14
(Sapienza University of Rome)
+ 3 AuthorsPaolo Capodaglio20
Estimated H-index: 20
Introduction In obese subjects, the relative reduction of the skeletal muscle strength, the reduced cardio-pulmonary capacity and tolerance to effort, the higher metabolic costs and, therefore, the increased inefficiency of gait together with the increased prevalence of co-morbid conditions might interfere with walking. Performance tests, such as the six-minute walking test (6MWT), can unveil the limitations in cardio-respiratory and motor functions underlying the obesity-related disability. The...
Cited By4
Newest
Published on Jul 1, 2019in Obesity3.97
A Rossi56
Estimated H-index: 56
(University of Verona),
Sofia Rubele3
Estimated H-index: 3
(University of Verona)
+ 8 AuthorsRiccardo Dalle Grave26
Estimated H-index: 26
Published on Jun 1, 2019in Nutrients4.17
Maria Letizia Petroni24
Estimated H-index: 24
,
Maria Turchese Caletti3
Estimated H-index: 3
+ 3 AuthorsGiulio Marchesini66
Estimated H-index: 66
Sarcopenic obesity (SO) is referred to as the combination of obesity with low skeletal muscle mass and function. However, its definition and diagnosis is debated. SO represents a sizable risk factor for the development of disability, possibly with a worse prognosis in women. The present narrative review summarizes the current evidence on pharmacological, nutrition and exercise strategies on the prevention and/or treatment of SO in middle-aged and older-aged women. A literature search was carried...
Published on May 15, 2019in World Journal of Diabetes
Dima Khadra , Leila Itani9
Estimated H-index: 9
+ 3 AuthorsMarwan El Ghoch15
Estimated H-index: 15
Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis
Shirine Khazem1
Estimated H-index: 1
,
Leila Itani9
Estimated H-index: 9
+ 4 AuthorsMarwan El Ghoch15
Estimated H-index: 15
Little is known about the reduction in lean body mass (LBM) and its health consequences in overweight and in obesity, especially in males. Therefore, we aimed to assess the prevalence of low LBM in treatment-seeking adult males with overweight and obesity and the association with cardiometabolic diseases, i.e., type 2 diabetes, cardiovascular diseases and dyslipidemia. A body composition assessment was conducted by a bio-impedance analyzer (InBody 170) among a total of 110 males, of whom 72 were...
Dima Kreidieh2
Estimated H-index: 2
,
Leila Itani9
Estimated H-index: 9
+ 3 AuthorsMarwan El Ghoch15
Estimated H-index: 15
The last decade has seen a new condition that describes the coexistence of obesity and sarcopenia, termed sarcopenic obesity (SO). We aimed to assess the prevalence of SO in overweight and obese treatment-seeking adult women and the association with type 2 diabetes, hypertension, and dyslipidemia. A body composition assessment was conducted with an InBody bioimpedance analyser in 154 overweight and obese women referred to the Outpatient Clinic in the Department of Nutrition and Dietetics at Beir...
Published on Jan 1, 2018
Riccardo Dalle Grave26
Estimated H-index: 26
,
Massimiliano Sartirana4
Estimated H-index: 4
+ 1 AuthorsSimona Calugi8
Estimated H-index: 8
An active lifestyle plays a central role in the management of obesity, favouring the maintenance of weight loss and reducing the health risk associated with the condition. Unfortunately, however, most patients with obesity have little motivation to change their physical activity habits, and their adherence to exercise is further hampered by several physical, psychological and environmental barriers. The key role of these processes in the failure–success of exercise adherence suggests that withou...
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