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Interactions at the Silica–Peptide Interface: Influence of the Extent of Functionalization on the Conformational Ensemble

Published on Jul 17, 2018in Langmuir 3.68
· DOI :10.1021/acs.langmuir.8b00874
Anna Sola-Rabada3
Estimated H-index: 3
(NTU: Nottingham Trent University),
Monika Michaelis2
Estimated H-index: 2
(NTU: Nottingham Trent University)
+ 4 AuthorsCarole C. Perry44
Estimated H-index: 44
(NTU: Nottingham Trent University)
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Abstract
In this contribution, the effect of silica particle size (28 and 210 nm) and surface chemistry (i.e., hydroxyl, methyl, or amino groups) on peptide binding response is studied with a specific emphasis on the effect of the extent of functionalization on binding. Exhaustive characterization of the silica surfaces was crucial for knowledge of the chemistry and topography of the solid surface under study and, thus, to understand their impact on adsorption and the conformational ensemble of the peptides. The extent of surface functionalization was shown to be particle-size dependent, a higher level of 3-aminopropyl functionality being obtained for smaller particles, whereas a higher degree of methyl group functionality was found for the larger particles. We demonstrated that peptide interactions at the aqueous interface were not only influenced by the surface chemistry but also by the extent of functionalization where a “switch” of peptide adsorption behavior was observed, whereas the changes in the conformati...
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Published on Oct 1, 2019in Journal of Colloid and Interface Science 6.36
Lívia M.D. Loiola1
Estimated H-index: 1
,
Marina Batista + 5 AuthorsMateus Borba Cardoso2
Estimated H-index: 2
(State University of Campinas)
Abstract Surface functionalization of silica nanoparticles (SiO 2 NPs) has been considered as a promising strategy to develop target-specific nanostructures. However, finding a chemical functionalization that can be used as an active targeting moiety while preserving the nanoparticles colloidal stability in biological fluids is still challenging. We present here a dual surface modification strategy for SiO 2 NPs where a zwitterion (ZW) and a biologically active group (BAG) (amino, mercapto or ca...
Giovanni Settanni15
Estimated H-index: 15
(University of Mainz),
Timo Schäfer (University of Mainz)+ -3 AuthorsFriederike Schmid27
Estimated H-index: 27
(University of Mainz)
Abstract Nanoparticles coated with hydrophilic polymers often show a reduction in unspecific interactions with the biological environment, which improves their biocompatibility. The molecular determinants of this reduction are not very well understood yet, and their knowledge may help improving nanoparticle design. Here we address, using molecular dynamics simulations, the interactions of human serum albumin, the most abundant serum protein, with two promising hydrophilic polymers used for the c...