Methotrexate and BAFF interaction prevents immunization against TNF inhibitors

Volume: 77, Issue: 10, Pages: 1463 - 1470
Published: Jun 23, 2018
Abstract
Objectives TNF inhibitors (TNFi) can induce anti-drug antibodies (ADA) in patients with autoimmune diseases (AID) leading to clinical resistance. We explored a new way of using methotrexate (MTX) to decrease this risk of immunisation. Methods We treated BAFF transgenic (BAFFtg) mice, a model of AID in which immunisation against biologic drugs is high, with different TNFi. We investigated the effect of a single course of MTX during the first...
Paper Details
Title
Methotrexate and BAFF interaction prevents immunization against TNF inhibitors
Published Date
Jun 23, 2018
Volume
77
Issue
10
Pages
1463 - 1470
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