A genome-wide mutation analysis method enabling high-throughput identification of chemical mutagen signatures
Abstract
Trinucleotide mutational signatures extracted from cancer genomes provide clues useful in understanding the roles of mutagens and mutagenic mechanisms in cancer development. The lack of a simple method for genome-wide analysis of alterations induced by mutagens hampers the identification of trinucleotide signatures of mutagen exposure and evaluation of their relationships with human cancers. Here, we describe a novel approach to facilitate...
Paper Details
Title
A genome-wide mutation analysis method enabling high-throughput identification of chemical mutagen signatures
Published Date
Jun 25, 2018
Journal
Volume
8
Issue
1
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