“Physiological Dysregulation” as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease

Volume: 74, Issue: 4, Pages: 462 - 468
Published: Jun 22, 2018
Abstract
Recently suggested novel implementation of the statistical distance measure (DM) for evaluating “physiological dysregulation” (PD) in aging individuals (based on measuring deviations of multiple biomarkers from baseline or normal physiological states) allows reducing high-dimensional biomarker space into a single PD estimate. Here we constructed DM using biomarker profiles from FRAMCOHORT (Framingham Heart Study) and CHS (Cardiovascular Health...
Paper Details
Title
“Physiological Dysregulation” as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease
Published Date
Jun 22, 2018
Volume
74
Issue
4
Pages
462 - 468
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