The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

Pages: 353789
Published: Jun 22, 2018
Abstract
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor whose activation induces the expression of numerous genes, with many effects on cells. However, AhR activation is not known to affect the replication of viruses. We show that AhR activation in macrophages causes a block to HIV-1 and HSV-1 replication. We find that AhR activation transcriptionally represses cyclin-dependent kinase (CDK)1/2 and their associated cyclins,...
Paper Details
Title
The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression
Published Date
Jun 22, 2018
Journal
Pages
353789
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.