Novel Self-Nano Emulsifying Drug Delivery System (SNEDDS) of andrographolide isolated from Andrographis paniculata Nees: Characterization, in-vitro and in-vivo assessment

This study aimed to conduct a preparation and characterization of andrographolide isolated from Andrographis paniculata Nees (AND)-loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS) to improve its oral dissolution and bioavailability. The selection of oil, surfactant and co-surfactant components for preliminary screening of self-nano emulsifying formulation was determined by solubility study of AND in various vehicles. Ternary phase...