AAV-Mediated Overexpression of BMP7 in White Adipose Tissue Induces Adipogenesis and Ameliorates Insulin Resistance

Obesity and type 2 diabetes are strongly associated and a major health problem because of their alarmingly growing prevalence worldwide. The hypertrophic expansion of white adipose tissue (WAT) promotes ectopic fat accumulation and development of insulin resistance whereas WAT hyperplasia is associated with preservation of insulin sensitivity. Several members of the Bone Morphogenetic Protein (BMP) family have been shown to play a role in white...