Progress and challenges of selective Farnesoid X Receptor modulation.
Abstract
Bile acids are amphipathic molecules that were previously known to serve as fat solubilizers in the intestine in postprandial conditions. In the last two decades, bile acids have been recognized as signaling molecules regulating energy metabolism pathways via, amongst others, the farnesoid X receptor (FXR). Upon bile acid activation, FXR controls expression of genes involved in bile acid, lipid, glucose and amino acid metabolism. In addition,...
Paper Details
Title
Progress and challenges of selective Farnesoid X Receptor modulation.
Published Date
Nov 1, 2018
Journal
Volume
191
Pages
162 - 177
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Notes
History