IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
Abstract
IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated genes that have key immune effector functions. This Review focuses on recent advances in our understanding of the...
Paper Details
Title
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
Published Date
Jun 19, 2018
Journal
Volume
18
Issue
9
Pages
545 - 558
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