Altered uric acid metabolism in isolated colonic Crohn's disease but not ulcerative colitis

Published on Jan 1, 2019in Journal of Gastroenterology and Hepatology3.63
· DOI :10.1111/jgh.14356
Feng Zhu1
Estimated H-index: 1
(Nanjing Medical University),
Dengyu Feng1
Estimated H-index: 1
(Nanjing Medical University)
+ 7 AuthorsNing Li1
Estimated H-index: 1
(Nanjing Medical University)
  • References (36)
  • Citations (1)
Published on Dec 21, 2017in PLOS ONE2.78
Yu Yun3
Estimated H-index: 3
(Kunming Medical University),
Hua Yin1
Estimated H-index: 1
(Yunnan University of Traditional Chinese Medicine)
+ 7 AuthorsWeigang Duan1
Estimated H-index: 1
(Yunnan University of Traditional Chinese Medicine)
The kidney was recognized as a dominant organ for uric acid excretion. The main aim of the study demonstrated intestinal tract was an even more important organ for serum uric acid (SUA) lowering. Sprague-Dawley rats were treated normally or with antibiotics, uric acid, adenine, or inosine of the same molar dose orally or intraperitoneally for 5 days. Rat’s intestinal tract was equally divided into 20 segments except the cecum. Uric acid in serum and intestinal segment juice was assayed. Total RN...
Published on Dec 1, 2017in Gastroenterology19.23
Susanna Nikolaus41
Estimated H-index: 41
Berenice Schulte2
Estimated H-index: 2
+ 15 AuthorsRobert Häsler30
Estimated H-index: 30
(CAU: University of Kiel)
Background & Aims Administration of tryptophan and some of its metabolites reduces the severity of colitis in mice, whereas removing tryptophan from the diet increases susceptibility to colitis. Transfer of the intestinal microbiome transfers the colitogenic phenotype from tryptophan starved animals to normally nourished mice. We aimed to systematically evaluate serum levels of tryptophan and its metabolites in patients with inflammatory bowel diseases (IBD), and study their association with cli...
Published on Nov 1, 2017in British Journal of Cancer5.42
Tilman Kühn25
Estimated H-index: 25
(DKFZ: German Cancer Research Center),
Disorn Sookthai9
Estimated H-index: 9
(DKFZ: German Cancer Research Center)
+ 5 AuthorsR. Kaaks113
Estimated H-index: 113
Albumin, bilirubin, uric acid and cancer risk: results from a prospective population-based study
Published on Nov 1, 2017in Journal of Pharmacological Sciences2.44
Yanfen Niu4
Estimated H-index: 4
(CAS: Chinese Academy of Sciences),
Hongjian Li9
Estimated H-index: 9
(CUHK: The Chinese University of Hong Kong)
+ 7 AuthorsLing Li7
Estimated H-index: 7
(Kunming Medical University)
Abstract Hyperuricemia, a long-term purine metabolic disorder, is a well-known risk factor for gout, hypertension and diabetes. In maintaining normal whole-body purine levels, xanthine oxidase (XOD) is a key enzyme in the purine metabolic pathway, as it catalyzes the oxidation of hypoxanthine to xanthine and finally to uric acid. Here we used the protein-ligand docking software idock to virtually screen potential XOD inhibitors from 3167 approved small compounds/drugs. The inhibitory activities ...
Published on Oct 12, 2017in PLOS ONE2.78
Stefania Fagagnini3
Estimated H-index: 3
(UZH: University of Zurich),
Henriette Heinrich10
Estimated H-index: 10
(UZH: University of Zurich)
+ 10 AuthorsStephan R. Vavricka36
Estimated H-index: 36
(UZH: University of Zurich)
Background Gallstones and kidney stones are known complications of inflammatory bowel diseases (IBD). Risk factors have been insufficiently studied and explanatory studies date back up to 30 years. It remains unclear, whether improved treatment options also influenced risk factors for these complications. Objectives Identifying risk factors for gallstones and kidney stones in IBD patients. Methods Using data from the Swiss Inflammatory Bowel Disease Cohort Study we assessed associations of disea...
Published on May 1, 2017in Diabetes and Vascular Disease Research2.36
Liubao Gu6
Estimated H-index: 6
Liji Huang1
Estimated H-index: 1
(Nanjing University of Chinese Medicine)
+ 2 AuthorsRongwen Bian6
Estimated H-index: 6
Background:Serum uric acid has shown to be a predictor of renal disease progression in most but not all studies. This study aims to test whether renal function-normalized serum uric acid is superior to serum uric acid as the predictor of incident chronic kidney disease in type 2 diabetes mellitus patients.Methods:In this study, 1339 type 2 diabetes mellitus patients with estimated glomerular filtration rate ⩾60 mL/min/1.73 m2 and normouricemia were included. Renal function-normalized serum uric ...
Published on Apr 12, 2017in Journal of nephropathology
Mahboube Ganji-Arjenaki2
Estimated H-index: 2
Hamid Nasri24
Estimated H-index: 24
M Rafieian Kopaie35
Estimated H-index: 35
Context: The extra-intestinal manifestations of inflammatory bowel disease (IBD) are common and involve other organs or systems for example; urinary system. Evidence Acquisitions: For this review, we used a variety of sources by searching through Web of Science, PubMed, EMBASE, Scopus and directory of open access journals (DOAJ). Results: Urinary complications may occur in up to 22% of patients and nephrolithiasis or renal/kidney stones have been suggested to be a common manifestation of disease...
Published on Mar 8, 2017in Science Translational Medicine17.16
Tyson R. Chiaro4
Estimated H-index: 4
(UofU: University of Utah),
Ray Soto3
Estimated H-index: 3
(UofU: University of Utah)
+ 12 AuthorsJune L. Round21
Estimated H-index: 21
(UofU: University of Utah)
The commensal microbiota has an important impact on host health, which is only beginning to be elucidated. Despite the presence of fungal, archaeal, and viral members, most studies have focused solely on the bacterial microbiota. Antibodies against the yeast Saccharomyces cerevisiae are found in some patients with Crohn’s disease (CD), suggesting that the mycobiota may contribute to disease severity. We report that S. cerevisiae exacerbated intestinal disease in a mouse model of colitis and incr...
Published on Feb 1, 2017in Gut17.94
Sreedhar Subramanian11
Estimated H-index: 11
(University of Liverpool),
Anders Ekbom98
Estimated H-index: 98
(KI: Karolinska Institutet),
Jonathan Rhodes59
Estimated H-index: 59
(University of Liverpool)
The genetics of isolated colonic Crohn9s disease place it approximately midway between Crohn9s disease with small intestinal involvement and UC, making a case for considering it as a separate condition. We have therefore systematically reviewed its epidemiology, pathophysiology and treatment. Key findings include a higher incidence in females (65%) and older average age at presentation than Crohn9s disease at other sites, a mucosa-associated microbiota between that found in ileal Crohn9s disease...
Published on Jan 1, 2017in Critical Care Medicine6.97
Kianoush Kashani22
Estimated H-index: 22
(Mayo Clinic),
Erin Frazee10
Estimated H-index: 10
+ 5 AuthorsJohn C. Lieske45
Estimated H-index: 45
Objectives:Sarcopenia is associated with a poor prognosis in the ICU. The purpose of this study was to describe a simple sarcopenia index using routinely available renal biomarkers and evaluate its association with muscle mass and patient outcomes.Design:A retrospective cohort study.Setting:A tertia
Cited By1
Published on Apr 2, 2019in Medicina-buenos Aires0.53
Katarzyna Neubauer11
Estimated H-index: 11
Radosław Kempiński3
Estimated H-index: 3
+ 2 AuthorsMalgorzata Krzystek-Korpacka18
Estimated H-index: 18
Background and objectives: Oxidative stress signalling plays a monumental role in inflammatory bowel disease (IBD). Reduction of oxidative stress might control inflammation, block tissue damage, and reverse natural history of IBD. We assessed the serum concentrations of free thiols (FT) and uric acid (SUA), together constituting a large part of nonenzymatic serum antioxidant capacity, as well as total antioxidant status (TAS) with reference to IBD phenotype, activity, co-occurrence of anemia, an...
View next paperUric Acid Metabolism Was Altered In Isolated Colonic Crohn's Disease But Not Ulcerative Colitis