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Altered uric acid metabolism in isolated colonic Crohn's disease but not ulcerative colitis

Published on Jan 1, 2019in Journal of Gastroenterology and Hepatology3.632
· DOI :10.1111/jgh.14356
Feng Zhu2
Estimated H-index: 2
(Nanjing Medical University),
Dengyu Feng1
Estimated H-index: 1
(Nanjing Medical University)
+ 7 AuthorsNing Li1
Estimated H-index: 1
(Nanjing Medical University)
Abstract
  • References (36)
  • Citations (1)
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References36
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#1Yu Yun (Kunming Medical University)H-Index: 3
#2Hua Yin (Yunnan University of Traditional Chinese Medicine)H-Index: 2
Last. Weigang Duan (Yunnan University of Traditional Chinese Medicine)H-Index: 2
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The kidney was recognized as a dominant organ for uric acid excretion. The main aim of the study demonstrated intestinal tract was an even more important organ for serum uric acid (SUA) lowering. Sprague-Dawley rats were treated normally or with antibiotics, uric acid, adenine, or inosine of the same molar dose orally or intraperitoneally for 5 days. Rat’s intestinal tract was equally divided into 20 segments except the cecum. Uric acid in serum and intestinal segment juice was assayed. Total RN...
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#1Susanna NikolausH-Index: 42
#2Berenice SchulteH-Index: 2
Last. Stefan Schreiber S (CAU: University of Kiel)H-Index: 150
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Background & Aims Administration of tryptophan and some of its metabolites reduces the severity of colitis in mice, whereas removing tryptophan from the diet increases susceptibility to colitis. Transfer of the intestinal microbiome transfers the colitogenic phenotype from tryptophan starved animals to normally nourished mice. We aimed to systematically evaluate serum levels of tryptophan and its metabolites in patients with inflammatory bowel diseases (IBD), and study their association with cli...
47 CitationsSource
#1Yanfen Niu (CAS: Chinese Academy of Sciences)H-Index: 4
#2Hongjian Li (CUHK: The Chinese University of Hong Kong)H-Index: 9
Last. Ling Li (Kunming Medical University)H-Index: 8
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Abstract Hyperuricemia, a long-term purine metabolic disorder, is a well-known risk factor for gout, hypertension and diabetes. In maintaining normal whole-body purine levels, xanthine oxidase (XOD) is a key enzyme in the purine metabolic pathway, as it catalyzes the oxidation of hypoxanthine to xanthine and finally to uric acid. Here we used the protein-ligand docking software idock to virtually screen potential XOD inhibitors from 3167 approved small compounds/drugs. The inhibitory activities ...
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#1Stefania Fagagnini (UZH: University of Zurich)H-Index: 3
#2Henriette Heinrich (UZH: University of Zurich)H-Index: 10
Last. Benjamin Misselwitz (UZH: University of Zurich)H-Index: 23
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Background Gallstones and kidney stones are known complications of inflammatory bowel diseases (IBD). Risk factors have been insufficiently studied and explanatory studies date back up to 30 years. It remains unclear, whether improved treatment options also influenced risk factors for these complications. Objectives Identifying risk factors for gallstones and kidney stones in IBD patients. Methods Using data from the Swiss Inflammatory Bowel Disease Cohort Study we assessed associations of disea...
6 CitationsSource
#1Tilman Kühn (DKFZ: German Cancer Research Center)H-Index: 28
#2Disorn Sookthai (DKFZ: German Cancer Research Center)H-Index: 11
Last. Rudolph KaaksH-Index: 118
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Albumin, bilirubin, uric acid and cancer risk: results from a prospective population-based study
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#2Hamid NasriH-Index: 28
Last. M Rafieian KopaieH-Index: 38
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Context: The extra-intestinal manifestations of inflammatory bowel disease (IBD) are common and involve other organs or systems for example; urinary system. Evidence Acquisitions: For this review, we used a variety of sources by searching through Web of Science, PubMed, EMBASE, Scopus and directory of open access journals (DOAJ). Results: Urinary complications may occur in up to 22% of patients and nephrolithiasis or renal/kidney stones have been suggested to be a common manifestation of disease...
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#1Tyson R. Chiaro (UofU: University of Utah)H-Index: 4
#2Ray Soto (UofU: University of Utah)H-Index: 3
Last. June L. Round (UofU: University of Utah)H-Index: 24
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#1Liubao GuH-Index: 6
#2Liji Huang (Nanjing University of Chinese Medicine)H-Index: 1
Last. Rongwen BianH-Index: 7
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Background:Serum uric acid has shown to be a predictor of renal disease progression in most but not all studies. This study aims to test whether renal function-normalized serum uric acid is superior to serum uric acid as the predictor of incident chronic kidney disease in type 2 diabetes mellitus patients.Methods:In this study, 1339 type 2 diabetes mellitus patients with estimated glomerular filtration rate ⩾60 mL/min/1.73 m2 and normouricemia were included. Renal function-normalized serum uric ...
15 CitationsSource
#1Sreedhar Subramanian (University of Liverpool)H-Index: 12
#2Anders Ekbom (KI: Karolinska Institutet)H-Index: 102
Last. Jonathan Rhodes (University of Liverpool)H-Index: 62
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The genetics of isolated colonic Crohn9s disease place it approximately midway between Crohn9s disease with small intestinal involvement and UC, making a case for considering it as a separate condition. We have therefore systematically reviewed its epidemiology, pathophysiology and treatment. Key findings include a higher incidence in females (65%) and older average age at presentation than Crohn9s disease at other sites, a mucosa-associated microbiota between that found in ileal Crohn9s disease...
15 CitationsSource
#1Kianoush Kashani (Mayo Clinic)H-Index: 24
#2Erin FrazeeH-Index: 10
Last. John C. LieskeH-Index: 44
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Objectives:Sarcopenia is associated with a poor prognosis in the ICU. The purpose of this study was to describe a simple sarcopenia index using routinely available renal biomarkers and evaluate its association with muscle mass and patient outcomes.Design:A retrospective cohort study.Setting:A tertia
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Background and objectives: Oxidative stress signalling plays a monumental role in inflammatory bowel disease (IBD). Reduction of oxidative stress might control inflammation, block tissue damage, and reverse natural history of IBD. We assessed the serum concentrations of free thiols (FT) and uric acid (SUA), together constituting a large part of nonenzymatic serum antioxidant capacity, as well as total antioxidant status (TAS) with reference to IBD phenotype, activity, co-occurrence of anemia, an...
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