Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis

Volume: 23, Issue: 11, Pages: 3407 - 3418
Published: Jun 1, 2018
Abstract
•Colorectal adenomas can be divided into three DNA methylation-based subclasses•Subclass-specific differences reflect colon cell-of-origin signatures•Colorectal cancer epigenomes maintain cell-of-origin signatures•Subclassification has clinical relevance Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity...
Paper Details
Title
Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis
Published Date
Jun 1, 2018
Volume
23
Issue
11
Pages
3407 - 3418
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