Haplotype phasing in single-cell DNA-sequencing data
Abstract
Motivation Current technologies for single-cell DNA sequencing require whole-genome amplification (WGA), as a single cell contains too little DNA for direct sequencing. Unfortunately, WGA introduces biases in the resulting sequencing data, including non-uniformity in genome coverage and high rates of allele dropout. These biases complicate many downstream analyses, including the detection of genomic variants. Results We show that amplification...
Paper Details
Title
Haplotype phasing in single-cell DNA-sequencing data
Published Date
Jun 27, 2018
Journal
Volume
34
Issue
13
Pages
i211 - i217
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Notes
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