Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance
Abstract
Nicotinamide adenine dinucleotide (NAD) is an important cofactor that regulates various biological processes, including metabolism and gene expression. As a coenzyme, NAD controls mitochondrial respiration through enzymes of the tricarboxylic acid (TCA) cycle, β-oxidation, and oxidative phosphorylation and also serves as a substrate for posttranslational protein modifications, such as deacetylation and ADP-ribosylation by sirtuins and...
Paper Details
Title
Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance
Published Date
Jun 14, 2018
Journal
Volume
17
Issue
4
Pages
e12798 - e12798
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