Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity
Abstract
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients. Here, we reveal a mechanism to selectively target and reprogram the function of tumor-infiltrating Tregs (TI-Tregs) by exploiting their dependency on the histone H3K27 methyltransferase enhancer of zeste homolog 2 (EZH2) in tumors. Disruption of EZH2 activity...
Paper Details
Title
Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity
Published Date
Jun 1, 2018
Journal
Volume
23
Issue
11
Pages
3262 - 3274
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Notes
History