Pioglitazone use and risk of bladder cancer: a systematic literature review and meta-analysis of observational studies

Studies investigating bladder cancer risk in pioglitazone-treated type 2 diabetes mellitus patients report conflicting results. Previous meta-analyses on this topic utilized publications prior to 2013. More long-term observational studies have been published since then. We reviewed the accumulated evidence and updated findings from previous meta-analyses.This meta-analysis was based on a systematic review of peer-reviewed observational studies...