Review paper
Diabetes Secondary to Acromegaly: Physiopathology, Clinical Features and Effects of Treatment
Abstract
Acromegaly is a rare disease due to chronic GH excess and to the consequent increase in IGF-1 levels. Both GH and IGF-1 play a role in intermediate metabolism affecting glucose homeostasis. Indeed, chronic GH excess impairs insulin sensitivity, increases gluconeogenesis, reduces the glucose uptake in adipose tissue and muscle and alters pancreatic β cells function. As a consequence, glucose metabolism alterations are a very frequent complication...
Paper Details
Title
Diabetes Secondary to Acromegaly: Physiopathology, Clinical Features and Effects of Treatment
Published Date
Jul 6, 2018
Journal
Volume
9
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