Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson’s Disease

Volume: 209, Issue: 4, Pages: 1345 - 1356
Published: Jun 15, 2018
Abstract
Mutations in LRRK2 (leucine-rich repeat kinase 2) cause Parkinson’s disease through poorly understood mechanisms. Lavoy et al. performed a genome-wide screen to identify genetic modifiers of LRRK2 G2019Sinduced locomotor dysfunction in Drosophila... Disease phenotypes can be highly variable among individuals with the same pathogenic mutation. There is increasing evidence that background genetic variation is a strong driver of disease variability...
Paper Details
Title
Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson’s Disease
Published Date
Jun 15, 2018
Journal
Volume
209
Issue
4
Pages
1345 - 1356
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