Original paper
Effective and efficient characterization of Chinese hamster ovary production cell lines using automated intracellular staining and statistical modeling
Abstract
Mammalian cell line development is critical to bioproduct manufacturing. Success requires selecting a line with desirable performance characteristics, including consistent expression throughout the proposed manufacturing window. Given the genetic and phenotypic flux inherent to immortalized lines such as Chinese hamster ovary cells, clonally-derived cell line characterization is vital. We describe here the development and implementation of a...
Paper Details
Title
Effective and efficient characterization of Chinese hamster ovary production cell lines using automated intracellular staining and statistical modeling
Published Date
May 1, 2018
Journal
Volume
34
Issue
3
Pages
570 - 583
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Notes
History