MET alterations detected in blood-derived circulating tumor DNA correlate with bone metastases and poor prognosis
Abstract
We analyzed clinical associations of MET alterations in the plasma of patients with diverse malignancies. Digital sequencing of circulating tumor DNA (ctDNA) (54–70 genes) was performed in 438 patients; 263 patients also had tissue sequencing (182–315 genes). The most represented tumor types were gastrointestinal (28.1%), brain (24.9%), and lung (23.2%). Most patients (71.2%) had recurrent/metastatic disease. MET alterations were observed in 31...
Paper Details
Title
MET alterations detected in blood-derived circulating tumor DNA correlate with bone metastases and poor prognosis
Published Date
Jun 4, 2018
Volume
11
Issue
1
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