Abstract 235: Interaction Between a Macrophage Chemokine Receptor, CCR2, and Its Ligand Plays a Crucial Role in Macrophage Recruitment Aand Regulated Inflammation in Normal Wound Healing

Background: Wound healing in chronic diseases, such as type 2 diabetes (T2D), is impaired due to dysregulated inflammation. Innate immune cells, particularly macrophages, play a significant role in regulated inflammation following tissue injury. After injury, CCR2+ monocytes are recruited to the peripheral wound. This recruitment is mediated in part by the CCR2 ligand, CCL2. Thus, we hypothesized that the CCL2/CCR2 interaction is vital for...