Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep
Abstract
The simplicity of the CRISPR/Cas9 system has enabled its widespread applications in generating animal models, functional genomic screening and in treating genetic and infectious diseases. However, unintended mutations produced by off-target CRISPR/Cas9 nuclease activity may lead to negative consequences. Especially, a very recent study found that gene editing can introduce hundreds of unintended mutations into the genome, and have attracted wide...
Paper Details
Title
Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep
Published Date
May 25, 2018
Journal
Volume
19
Issue
1
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Notes
History