The Structure of the Pro-domain of Mouse proNGF in Contact with the NGF Domain
Abstract
Nerve growth factor (NGF) is an important neurotrophic factor involved in the regulation of cell differentiation and survival of target neurons. Expressed as a proNGF precursor, NGF is matured by furin-mediated protease cleavage. Increasing evidence suggests that NGF and proNGF have distinct functional roles. While the structure of mature NGF is available, little is known about that of the pro-domain because of its dynamical structural features....
Paper Details
Title
The Structure of the Pro-domain of Mouse proNGF in Contact with the NGF Domain
Published Date
Jan 1, 2019
Journal
Volume
27
Issue
1
Pages
78 - 89.e3
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