CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
Abstract
Here, we report that genome editing by CRISPR-Cas9 induces a p53-mediated DNA damage response and cell cycle arrest in immortalized human retinal pigment epithelial cells, leading to a selection against cells with a functional p53 pathway. Inhibition of p53 prevents the damage response and increases the rate of homologous recombination from a donor template. These results suggest that p53 inhibition may improve the efficiency of genome editing...
Paper Details
Title
CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
Published Date
Jun 11, 2018
Journal
Volume
24
Issue
7
Pages
927 - 930
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