Mouse medulloblastoma driven by CRISPR activation of cellular Myc

Volume: 8, Issue: 1
Published: Jun 7, 2018
Abstract
MYC-driven Group 3 (G3) medulloblastoma (MB) is the most aggressive of four molecular subgroups classified by transcriptome, genomic landscape and clinical outcomes. Mouse models that recapitulate human G3 MB all rely on retroviral vector-induced Myc expression driven by viral regulatory elements (Retro-Myc tumors). We used nuclease-deficient CRISPR/dCas9-based gene activation with combinatorial single guide RNAs (sgRNAs) to enforce...
Paper Details
Title
Mouse medulloblastoma driven by CRISPR activation of cellular Myc
Published Date
Jun 7, 2018
Volume
8
Issue
1
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